Archive for October, 2008

CORRECTED - PersonalFinance: Save while you shop

Thursday, October 30th, 2008

It has been 7 years since Upromise.com launched as one of the Internet’s first shopping/saving sites.

Conceived as a marketing tool to help consumers funnel rebates and discounts into their college savings accounts, it was complex and confusing, but profitable for those consumers who invested time in learning how to make the most of it.

Now, with 600 online retail partners, 30,000 restaurants and grocery stores, its own credit card program, and more than one million members, Upromise has grown in complexity, and also in its potential to reward. The site has demonstrated its ability to thrive and deliver while other Web shopping portals have come and gone. It’s worth a second look for anyone trying to save a few bucks in the current tight economy, even if they aren’t college-focused.

“I’m so passionate about it, everyone should have an account,” says one of the site’s first-year members, financial advisor Lisa Roll of Glen Gardner, New Jersey. Over the years, Roll and her husband, Tom, have earned $7,000 in Upromise cash and now are depositing roughly $70 a month in rebates and discounts into the college savings accounts they’ve set up for their 7-year-old son and 5-year-old daughter.

The site has a lot of moving parts and various programs, so it does take a certain investment of time to make the most of its offerings. Here’s what you have to know to really cash in on the Upromise.

– It isn’t just for college. Though the site is mainly pitched at folks who direct Upromise to sweep their savings straight into college savings 529 programs, it doesn’t have to be used that way. The company will send you a check every quarter for your total savings, as long as they total $25 or more. That means that shoppers who are currently trying to decide between a raft of online shopping portals and credit card rebate programs could simplify their lives by using the Upromise card and portal.

With its breadth of merchants, it claims to be the largest and most comprehensive program in the United States. It’s nice to stash away money for college, but if you’d rather use it for retirement savings, your annual vacation, or filling up your gas tank, you can.

– The credit card is key. The site is paired with a Citi Upromise World MasterCard, which is worth getting if you’re going to use the program. It offers 1 percent back on all purchases, with no annual cap, as well as added discounts on the stores, restaurants and products that are partnered with Upromise. Register the card in the Upromise restaurant program and you get 10 percent back on your total check, including tax and tip. And there are 8,000 restaurants in the program. It offers similar benefits at grocery stores.

– Register your other cards. If you register your other credit cards with Upromise as well, you’ll automatically get the Upromise rebate (typically 2 to 4 percent, but sometimes as much as 25 percent) on your purchases at partner merchants — even if you didn’t remember to ask for it.

– Shop big. Some of the Upromise partners offer big ticket items and sizable savings. Century 21 Realtors offers registered customers 11.11 percent of their local office’s commission on their home’s purchase or sale. Lumber Liquidators (flooring) and Blue Nile (diamonds) offer 2 percent rebates. Check the complete list at https://lty.s.upromise.com/viewAllCompanies.do before making any large purchases.

– Use the grocery programs. Register your local grocery store membership card with Upromise, and you’ll see extra savings (typically 1 percent to 2 percent) on a variety of products like Nestle’s chocolate chips and Domino sugar. Use that same Citi Upromise card at the groceries, and bump those product savings up to 10 percent. Upromise also has a new e-coupon program that works like this: Check the site before you head to the store. Click on the coupons you want to use (the current choice includes free Aquafina water, $1 off Huggies, etc.), and they will be automatically synced with your grocery card. Wave it at the register and those savings will accumulate in your Upromise fund.

– Maximize the online savings. Upromise offers a toolbar, called the “TurboSaver” that you can download to your computer desktop. If you stop to shop at a partner store, even if you haven’t gone through the Upromise Website, it will remember that you are registered and direct the appropriate rebate to your Upromise account.

– Know that it isn’t the only game in town. ‘Lest this column sound too much like an advertisement for Upromise, there are caveats to mention. Other credit cards may offer bigger rebates on some items; for example the American Express Costco TrueEarnings card pays 3 percent back on gasoline and 2 percent back on travel. And you’ll play a sucker’s game if you buy costly prepared foods that you wouldn’t otherwise buy just to get the Upromise rebate. Your time is worth something too, so spending hours trying to track which orange juice offers a coupon can be counter-productive. But as a one-stop shop for building cash on the fly, especially when times are difficult and we’re heading into holiday season, Upromise can hold a lot of, um… promise.

Antibody that can reduce food craving, expand calorie burn identified

Thursday, October 30th, 2008

Scientists at The Scripps Research have identified an antibody that works against the gastric hormone ghrelin, which has been linked to weight gain and fat storage through its metabolic actions.

Research leaders Kim Janda and Eric P. Zorrilla say that their findings point towards a potentially novel treatment for obesity that would interfere directly with the some of the biological mechanisms determining weight.

The researchers observed during the study that the antibody catalyst GHR-11E11 led to a higher metabolic rate in fasting mice, and suppressed feeding following 24-hour food deprivation.

“Our study showed that this novel catalytic ghrelin antibody could specifically seek out and degrade ghrelin,” said Janda, who is Ely R. Callaway, Jr. Professor of Chemistry, member of The Skaggs Institute for Chemical Biology, and director, Worm Institute of Research and Medicine (WIRM), at Scripps Research.

“While this antibody lacks a high level of catalytic efficiency, our study clearly demonstrates that even a basal level of catalysis can effectively modulate feeding behavior. These findings not only validate antibody-based therapeutics, but strongly suggest that catalytic anti-ghrelin antibodies might help patients reach and maintain their weight loss goals,” Janda added.

Ghrelin is a gastric endocrine hormone produced primarily in the stomach, which encourage eating during periods of calorie restriction. It promotes weight gain and fat storage through its metabolic actions, decreasing the break down of stored fat for energy as well as energy expenditure itself.

The new study suggests the possibility that passive immunopharmacotherapy with the catalytic anti-ghrelin antibody such as GHR-11E11 could decrease the level of serum ghrelin, and modulate energy homeostasis.

“The reason we looked at passive immunopharmacotherapy to treat obesity was because agonist/antagonist types of drugs have been remarkably unsuccessful,” Janda said.

“They are effective only while treatment is maintained and when treatment stops, weight returns. For obesity treatments to work, they must affect food intake and energy expenditure or storage-which is what this new catalytic antibody does by degrading ghrelin. Some people have the idea that because ghrelin is an endogenous hormone there might be too many adverse side effects if you eliminate it, but there is new evidence that the body itself produces antibodies against ghrelin,” the researcher added.

Since immunoneutralization would occur outside the central nervous system, the researchers believe that their approach might eliminate potential side effects that might occur with blood-brain barrier-penetrating small molecule antagonists.

Given the complex nature of obesity, any antibody-based strategy would most likely be used in combination with other available drugs, and as part of a comprehensive treatment approach that included nutritional, exercise, educational, and psychosocial components, Janda said.

He, however, conceded that more research was needed and, in addition to the development of more effective ghrelin antibodies, scientists needed to better understand issues like the effect of the antibodies over the long-term and their impact on individuals with varying body weights.

The study has been published in the online edition of the journal Proceedings of the National Academy of Sciences (PNAS).

Small things that count in business organization

Saturday, October 25th, 2008

<!– /* Font Definitions */ @font-face {font-family:”Cambria Math”; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:1; mso-generic-font-family:roman; mso-font-format:other; mso-font-pitch:variable; mso-font-signature:0 0 0 0 0 0;} @font-face {font-family:Calibri; panose-1:2 15 5 2 2 2 4 3 2 4; mso-font-charset:0; mso-generic-font-family:swiss; mso-font-pitch:variable; mso-font-signature:-1610611985 1073750139 0 0 159 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:”"; margin-top:0in; margin-right:0in; margin-bottom:10.0pt; margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:”Calibri”,”sans-serif”; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:”Times New Roman”; mso-bidi-theme-font:minor-bidi;} a:link, span.MsoHyperlink {mso-style-noshow:yes; mso-style-priority:99; color:blue; text-decoration:underline; text-underline:single;} a:visited, span.MsoHyperlinkFollowed {mso-style-noshow:yes; mso-style-priority:99; color:purple; mso-themecolor:followedhyperlink; text-decoration:underline; text-underline:single;} p {mso-style-priority:99; mso-margin-top-alt:auto; margin-right:0in; mso-margin-bottom-alt:auto; margin-left:0in; mso-pagination:widow-orphan; font-size:12.0pt; font-family:”Times New Roman”,”serif”; mso-fareast-font-family:”Times New Roman”;} .MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:”Times New Roman”; mso-bidi-theme-font:minor-bidi;} .MsoPapDefault {mso-style-type:export-only; margin-bottom:10.0pt; line-height:115%;} @page Section1 {size:8.5in 11.0in; margin:1.0in 1.0in 1.0in 1.0in; mso-header-margin:.5in; mso-footer-margin:.5in; mso-paper-source:0;} div.Section1 {page:Section1;} –> Businesses need more than money to survive. They need that business sense and proper organization and planning to excel. Small things are also significant in business. Take for example business cards. A business card gives the first impression of your business. Thus, a business card should be able to reflect your business values. Wouldn’t it be great to create a business card on your own and print it at your own convenience? The concept of printable business cards helps you do just that.

This concept lets you design your business card with the help of some templates and provides you with high quality business card paper compatible with all types of printers so that you can print your business cards as and when you need them. A printable business card helps make business easy.

Media labels are another way to organize your business’ workplace. Your business media does not only look organized but also makes sense for clients if labeled properly. Labels that are easy to print as well as convenient to use make for good business planning. It is a good practice to use media labels to categorize, classify, order, and group all types of media in any business.

Cheap Custom Wheels

Saturday, October 25th, 2008

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Snail toxin could provide relief from pain

Saturday, October 25th, 2008

The toxins with which cone snails immobilise their prey, could potentially offer better pain relief in the future, according to research.

Neuroscientists at University of Queensland’s Brain Institute (QBI) have revealed that a toxin produced by a lethal cone snail acts on a newly identified target and cell signalling pathway that may play a critical role in regulating chronic pain.

The venom of cone snails - marine animals found in several of the world’s oceans - is currently the subject of extensive scientific investigation because its powerful analgesic (pain relieving) properties are thought to offer several distinct advantages over traditional therapeutic treatments for neuropathic pain.

Professor David Adams and his team have identified specific peptides in the cone shell toxin that may serve as the molecular framework for novel “designer” conotoxins, according to a Queensland press release.

“For several years, it’s been known that the remarkable properties of cone shell toxins (conotoxins) hold tremendous promise for chronic pain sufferers, and drugs that can combat or alleviate pain are a holy grail in drug discovery,” Adams said.

The prevailing scientific view until now has been that conotoxins only targeted one group of pain receptors. However, Adams, along with David Craik (UQ’s Institute for Molecular Bioscience) and colleagues have described a surprising new way of inhibiting pain sensors using mini-proteins commonly found in cone snail venoms.

These findings were published in the Journal of Neuroscience.

Mac Training

Friday, October 24th, 2008

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This isn’t a problem since there are many options for Mac OS X leopard training. This latest operating system from Mac offers a lot of cool features and a sleek decision, but it is worthless if the employee doesn’t know how to make the most of it. Just spending a little money on a refresher course should have all your workers doing much better on the new system and greatly improving your overall efficiency. This could take place in the form of a seminar or a course. There are also online options that they can take in the background of normal business. This may be a better way to get the training done if your employees already know some of the basics.

If you want to make the jump to Macintosh, then you should remember to include Mac leopard training in the package.

Abbey Clancy getting custom built bed made for 6ft 7in Peter Crouch

Friday, October 24th, 2008

Abbey Clancy and her footballer beau Peter Crouch have got a custom made bed to fit in.

Clancy revealed that she and her 6ft 7in beau Crouch, 27, are having a bed made to prevent his legs getting out of the bed.

“It’ll be the first time Pete’s feet are not going to stick out the end,” British tabloid The Sun quoted Clancy as saying.

Clancy was spotted with a nick on her chest.

However, she told it was the couples kittens, which caused it, she told radio one DJ Moyles.

Videogame makers bank on sequels

Friday, October 24th, 2008

Sequels may not always match up to the original in Hollywood but videogames can often get better the second or third time around.

Videogame producers are hoping it will hold true with the latest games that will hit store shelves soon including Insomniac Games‘ “Resistance 2″ PlayStation 3 exclusive, Epic Games‘ “Gears of War 2″ Xbox 360 exclusive, Microsoft’s “Fable 2,” and Bethesda Softworks‘ “Fallout 3.”

“Developers can hit the ground running with sequels,” said Ted Price, president and CEO of Insomniac Games. “The game’s story and art style have a solid base, the tech and tools are stable and the basic gameplay mechanics have gone through plenty of tuning in the first game.”

The second or third time around developers can devote more energy to building game assets instead of trying to get things up and running.

“It’s certainly a liberating experience when you’re no longer arguing over the main character’s name, or waiting for basic systems to be implemented,” said Price. “The end result is usually a game that’s bigger, more polished and has more innovative features than the original game.”

“Resistance 2,” thrusts players into an alternate 1950s America invaded by aliens called Chimera. In addition to a single-player campaign, the game offers an eight-player cooperative campaign and online gameplay with battlefields filled with 60 players.

Aliens also feature in “Gears of War 2″, which sends gamers into the depths of the planet Sera to tackle a race called the Locusts. The sequel offers a story that can be played with a friend. Online gameplay modes like “Horde” also pit up to five players against waves of heavily armed Locusts.

“We want casual gamers to play the game and be sucked into the universe and finish the game,” said Cliff Bleszinski, lead games designer, Epic Games. “We want them to potentially finish with a friend and become a fan of the characters and the setting.”

Attracting the mainstream audience was also a major goal of Peter Molyneux, creator of Microsoft’s “Fable II” for Xbox 360. He’s crafted a game that he believes will satisfy the 3 million gamers who bought the original, while opening up the fantasy role-playing adventure genre to anyone.

“We’ve designed this game to allow the player to do whatever they wish, including getting married and having kids, playing mini-games and creating a custom character that will evolve as you play,” said Molyneux.

Call of Duty: World at War,” the latest game in the franchise focuses on the bloody Pacific Front and the Russian invasion of Nazi-occupied Berlin during the Second World War.

“The developer spent two years working on the technology behind this game, which includes four-player cooperative play and the introduction of new weapons like flame throwers and flame tanks,” said Daniel Suarez, executive producer of the game at Activision

Gamers have been waiting 10 years for Bethesda Softworks‘ “Fallout 3,” for PC, Xbox 360 and PlayStation 3.

“I think it’s good for people to miss things,” said Todd Howard, executive producer of the game. “Ten years between ‘Fallout’ is a bit long, but I think there’s this nostalgia factor.”

Fans of the post-Apocalyptic game, set in Washington, D.C., won’t have to wait another decade for “Fallout 4.” Howard said he believes three years is a good time frame between games.

Storage breakthrough brings quantum computers closer to reality

Friday, October 24th, 2008

Scientists have now made it possible to store information inside the nucleus of an atom-a breakthrough that has paved the way for a quantum computer which could crack problems unsolvable by current technology.

Touted as the holy grail of computing, quantum computing involves individual piece of information, or ‘bit’, which can have more than one value at once, as opposed to current technology which is limited to either 1s or 0s. This can dramatically escalate the processing power and thus widens the scope of what computers can do.

Researchers from Oxford and Princeton universities and Lawrence Berkeley National Laboratory could successfully isolate a quantum bit from a noisy environment to protect the delicate quantum information, while at the same time allowing it to interact with the outside world so that it can be manipulated and measured.

The team’s plan was to devise a hybrid system using both the electron and nucleus of an atom of phosphorous embedded in a silicon crystal.

While both the electron and nucleus behave as a tiny quantum magnet capable of storing quantum information, but inside the crystal, the electron is much bigger than the nucleus with an equally stronger magnetic field. This makes the electron well-suited for manipulation and measurement, but not so good for storing information, which can become rapidly corrupted.

Thus, when the information in the electron is ready for storage, it is moved into the nucleus where it can survive for much longer times.

For the experiments, the scientists used silicon enriched with the single 28Si iso-tope, grown by the Berkeley team into large crystals while keeping the material ultra-pure and free from contaminants.

“The electron acts as a middle-man between the nucleus and the outside world. It gives us a way to have our cake and eat it - fast processing speeds from the electron, and long memory times from the nucleus,” Nature quoted John Morton, a research fellow at St. John’s College, Oxford and lead author of the study, as saying.

They observed that the information stored in the nucleus had a lifetime of about 1 and 3/4 seconds, far more than a recently calculated target for quantum computing in silicon beyond which known error correction techniques could then protect the data for an arbitrarily long period of time.

In the absence of this technique, the researchers could preserve quantum information in silicon as long as a few tens of milliseconds.

“Nobody really knew how long a nucleus might hold quantum information in this system. With the crystals from Lawrence Berkeley and very careful measurements we were delighted to see memory times exceeding the threshold,” said Steve Lyon, leader of the Princeton team.

The biggest advantage of the model used in this study is that it is based on silicon technology, which makes it more compatible with today’s computers.

The study is published in the latest issue of the journal Nature.

A helpline this Diwali to help treat burns

Thursday, October 23rd, 2008

Got a slight burn while bursting crackers this Diwali? Don’t panic and don’t try home remedies. Help is now just a phone call away.

Known plastic surgeon Anup Dhir has launched a 24-hour helpline to provide ready and quick tips on how to treat burn injuries during the festival of lights.

The helpline will be functional from Oct 23. Diwali is on Oct 28.

Dhir, who is a senior consultant cosmetic surgeon in the Indraprastha Apollo Hospital and has been running the helpline since 1998, said people have no clue of how to tend to cracker burns.

“A small tip can help ease the person’s pain. I am not treating but advising them what should be done and what should be avoided if one gets burns,” he added.

For assistance, call 09312377554, he said. It will be functional till Oct 30 and the doctor will pick up the phone himself.

“The most important thing regarding burn injuries is that 95 percent of them are accidental and can be prevented with care and precautions. People try their own home remedies which wouldn’t help. One needs professional help,” Dhir told IANS.

The doctor said he started the concept 10 years ago after he saw in the hospital that maximum number of patients after Diwali were those who had burnt themselves while bursting crackers.

“People don’t know how and in which situation to pour water. I will simply guide them and then they could go to their nearest hospital. People panic and act foolishly, which worsens the situation. Some people even apply toothpaste. It is not the solution,” he said.

He said he gets dozens of phone calls before and after Diwali and these peak on Diwali.

Dhir said statistics show that 38 percent of injuries involve hands and fingers and 19 percent eyes.

About half of the injuries are burns, especially in the face, hand, wrist or arm, he said. “Contusions and lacerations are the next most common kind of injuries.”

Forty percent of those who suffered such injuries are children below the age of 14, and it is mostly boys in the age group of 10 to 14, the expert said.

“Diwali is the festival of lights and happiness and that is what it should be. Playing with firecrackers, especially the big ones, should be avoided,” he advised.

He suggested that firecrackers should be lit in an open area and a bucket of water should always be kept nearby.

“The best is to say no to firecrackers. This would surely mean a happy and safe Diwali,” Dhir said.